Search results for "Shear stress"
showing 10 items of 108 documents
Variable-charge method applied to study coupled grain boundary migration in the presence of oxygen
2009
International audience; One of the important differences between simulation and experiments in grain boundary (GB)-dominated metallic structures is the lack of impurities such as oxygen in computational samples. A modified variable-charge method [Elsener A, Politano O, Derlet PM, Van Swygenhoven H. Modell Simul Mater Sci Eng 2008;16:025006] based on the Streitz and Mintmire approach [Streitz FH, Mintmire JW. Phys Rev B 1994;50:11996] is used to study coupled GB motion in an Al bicrystal with a [1 1 2] symmetrical tilt GB in the presence of substitutional O, and compared with the stick–slip process identified by Cahn and Mishin [Cahn JW, Mishin Y, Suzuki A. Acta Mater 2006;54:4953]. It is found…
Development of branching brittle and ductile shear zones: A numerical study
2017
Continental collision zones are usually associated with large-scale strike-slip shear zones. In most cases these shear zones are complex and consist of multiple strands, varying in width, length, and total displacement. Here we present 2-D numerical models to simulate the formation of such shear zones at different depth levels within the crust, under either brittle (frictional/plastic) or ductile conditions. Localization of shear zones is initiated by a material contrast (heterogeneity) of the material parameters. We systematically test the rate of strain-weakening in brittle and in ductile regimes to understand its influence on the development of shear zone networks. Our simulations sugges…
Assessing and Modeling Soil Detachment Capacity by Overland Flow in Forest and Woodland of Northern Iran
2020
Land use has significant effects on the erosion process, since it influences the soil detachment capacity by causing an overland flow (Dc). The effects of different land uses on the rill detachment capacity have not been explained in depth, and the hydraulic parameters providing accurate estimates of this soil property have not been completely identified. This study quantifies Dc at low flow rates in woodland and forestland, compared to two other land uses (cropland and grassland), in the Saravan watershed (Northern Iran), and develops prediction models of Dc and rill erodibility (Kr). Dc was measured on undisturbed soil samples, collected in the four land uses, and characterized in terms o…
A versatile bioreactor for dynamic suspension cell culture. Application to the culture of cancer cell spheroids.
2016
A versatile bioreactor suitable for dynamic suspension cell culture under tunable shear stress conditions has been developed and preliminarily tested culturing cancer cell spheroids. By adopting simple technological solutions and avoiding rotating components, the bioreactor exploits the laminar hydrodynamics establishing within the culture chamber enabling dynamic cell suspension in an environment favourable to mass transport, under a wide range of tunable shear stress conditions. The design phase of the device has been supported by multiphysics modelling and has provided a comprehensive analysis of the operating principles of the bioreactor. Moreover, an explanatory example is herein prese…
Visualizing the spatiotemporal map of Rac activation in bovine aortic endothelial cells under laminar and disturbed flows.
2017
Disturbed flow can eliminate the alignment of endothelial cells in the direction of laminar flow, and significantly impacts on atherosclerosis in collateral arteries near the bifurcation and high curvature regions. While shear stress induced Rac polarity has been shown to play crucial roles in cell polarity and migration, little is known about the spatiotemporal map of Rac under disturbed flow, and the mechanism of flow-induced cell polarity still needs to be elucidated. In this paper, disturbed flow or laminar flow with 15 dyn/cm2 of average shear stress was applied on bovine aortic endothelial cells (BAECs) for 30 minutes. A genetically-encoded PAK-PBD-GFP reporter was transfected into BA…
Effect of intermittent shear stress on corneal epithelial cells using an in vitro flow culture model.
2018
Abstract Purpose The aim of this study was to establish and to evaluate an in vitro model for culturing human telomerase-immortalized corneal epithelial (hTCEpi) cells under adjustable medium flow mimicking the movements of the tear film on the ocular surface. Methods Using an IBIDI pump system, cells were cultured under unidirectional, continuous or oscillating, discontinuous medium flow. Cell surface and cytoskeletal architecture were investigated by scanning electron microscopy and immunofluorescence. Gene expression of e-cadherin, occludin, tight junction protein (TJP), desmoplakin, desmocollin and mucins was investigated by real-time PCR. Protein expression of desmoplakin, TJP, occludi…
Plasma viscosity pattern and erythrocyte aggregation in two patients with congenital afibrinogenemia
2020
: In this case report, we examine the behavior of plasma viscosity, explored at high and low shear rates, and erythrocyte aggregation in two patients with congenital afibrinogenemia, a clinical disorder firstly described in 1920 and that has an estimated incidence of 1 : 1-200 0000. The two hemorheological parameters examined by us showed a marked decrease in both patients, in one of whom erythrocyte aggregation was even undetectable. Keeping in mind that spontaneous thrombosis (venous and arterial) has been often described in congenital afibrinogenemia, it can be hypothesized that the decrease in plasma viscosity and erythrocyte aggregation might cause a reduction of the endothelial synthe…
Impact of Thoracic Endografting on the Hemodynamics of the Native Aorta: Pre- and Postoperative Assessments of Wall Shear Stress and Vorticity Using …
2021
Purpose To quantify the hemodynamic consequences of thoracic endovascular aortic repair (TEVAR) by comparing the preoperative and postoperative wall shear stress (WSS) and vorticity profiles on computational fluid dynamics (CFD) simulations. Materials and Methods The pre- and postoperative computed tomography (CT) scans from 20 consecutive patients (median age 69 years, range 20–87) treated for different thoracic aortic pathologies (11 aneurysms, 5 false aneurysms, 3 penetrating ulcers, and 1 traumatic aortic rupture) were segmented to construct patient-specific CFD models using a meshless code. The simulations were run over the cardiac cycle, and the WSS and vorticity values measured at th…
Shear coefficient determination in linear friction welding of aluminum alloys
2015
In the present study, a combined experimental and numerical investigation on Linear Friction Welding (LFW) of AA2011-T3 aluminum alloy was carried out in order to find the temperature dependent shear coefficient to be used in a 3D numerical model of the process. Torque, oscillation frequency and pressure were acquired in order to calculate the shear stress at the interface. A numerical thermal model was used to calculate the temperature at the interface between the specimens starting from experimental temperatures acquired through a thermocouple embedded in the LFW specimens. Finally, the calculated shear coefficient was used to model the contact between the two specimens in a dedicated 3D,…
Comparison of hemodynamic and structural indices of ascending thoracic aortic aneurysm as predicted by 2-way FSI, CFD rigid wall simulation and patie…
2018
Patient-specific computational modeling is increasingly being used to predict structural and hemodynamic parameters, especially when current clinical tools are not accessible. Indeed, pathophysiology of ascending thoracic aortic aneurysm (ATAA) has been simulated to quantify the risk of complications by novel prognostic parameters and thus to improve the clinical decision-making process related to the intervention of ATAAs. In this study, the relevance of aneurysmal wall elasticity in determining parameters of clinical importance, such as the wall shear stress (WSS), is discussed together with the significance of applying realistic boundary conditions to consider the aortic stretch and twis…